优秀研究生学位论文题录展示

Expression of MUCI mucin and its significance in pancreatic carcinoma

专 业: General Surgery  英文
关键词: MUC1 mucin pancreatic carcinoma clinicopathological parameters immunohistoc
分类号: R73
形 态: 共 72 页 约 47,160 个字 约 2.256 M内容
阅 读: 全文阅读说明

内容摘要


Pancreatic carcinoma is kaaown to be one of the most devastating diseases aroundthe world witll 5.vear survival rate less than 5%u,21,Presently,surgical operation hasbeen the dominant procedure for treating pancreatic carcinoma.but only with 5%~1 5%of total cases of tumor are detectcd early enough to allow radical resection口一】.Invasionand metastasis ofpancreatic carcinoma have also been accepted to be the most obstaclesto succeed the treatment;even radiation and chemotherapy are Iimited effectiveness[s-7].Although the process of tulnor initiation and metastasis is still largely unknown,theadvances in molecular biology and in our understanding of the pathogenesis of cancerprogression have provided new tools with which to predict the aggressive potential ofhumma ca.rlcers.Currently,different molecular changes of protein with tumor development,such asMUCl nmcin were found to play an important role in tumor cell migration a玎d regulatethe potential for epithelial cells to metastasize⋯“.MUCl mucin is the only integralmembrane glycoprotein among a large number of other mucins that is expressed at highlevels on the surface of epithelial cell tumors,primary pancreas,colon,duodenum,breast.ovary and lung adenocarcinoma⋯一1 51.The overexpression ofMUCl is assumedto influence the biological behaviors oftumor cells during malignant transformation andtumor progression【916—18]Although MUCl mucin has been studied widely in neoplastictissues,only a few detailed studies demonstrated clinical relevance ofMUCl in humanpancreatic tumoL while the in vitro studies clarified that MUCI mucin plays asignificant role in reduction aggregating capacity of adhesion molecules in pancreaticcancer cell line 11 9].In the present study,we detected MUC 1 mucin in pancreatic tumorparaffin,embedded tissue by immunohistochemistry method.Image analysis system wasassessed to obtain the quantitative expression level of MUCl mucin,in addition toexplore the correlation with the clinical outcome ofhuman pancreaticCarcinoma……

全文目录


Preface
Abbreviation
Part Ⅰ: The relationship between the expression of MUC1 mucin and clinicopathological features of pancreatic carcinoma
Introduction
Materials and Methods
Results
Discussion
Conclusion
References
Part Ⅱ: Expression of MUCI mucin and its correlation with Tumor Angiogenesis in pancreatic carcinoma
Introduction
Materials and Methods
Results
Discussion
Conclusion
References
Review
Acknowledgement
附件

相似论文

  1. 重组p21ras蛋白的表达、鉴定与纯化及其多克隆抗体的制备,88页,R7 Q78
  2. Survivin基因靶向RNA干扰重组表达载体构建和测序,32页,R703.2
  3. 产程中电子胎心监护晚期减速图形的数据还原和计算机分析,55页,R71
  4. 单细胞聚合酶链反应用于胚胎种植前诊断的实验研究,54页,R71
  5. 晚卵泡期性激素变化及其对排卵障碍的预测价值探讨,24页,R71
  6. 晚卵泡期血清孕激素对体外受精-胚胎移植结局的影响及其机制的初步探讨,39页,R71
  7. Leptin及其受体在人卵巢中的表达及作用,45页,R71
  8. 67kDaLN-R在卵巢癌组织中的表达及其反义核酸治疗卵巢癌的实验研究,86页,R71
  9. 妊娠早期子宫微环境趋化因子表达及其生物学意义的研究,86页,R71
  10. 金喜素/顺铂用于上皮性卵巢癌一线化疗的临床研究,43页,R71
  11. 小鼠囊胚玻璃化冷冻研究及超微结构观察,69页,R71
  12. HIV-1宫内传播相关因素研究,95页,R71
  13. 妊娠期肝内胆汁淤积症患者胎盘上缺氧诱导因子的初步研究,88页,R71
  14. 外周血sICAM-1浓度和胎盘组织VEGF PLGF Flt-1、sFlt-1mRNA的表达与妊高征发病的关系,54页,R71
  15. 超声造影剂介导PTEN基因影响卵巢癌的实验研究,80页,R71
  16. 人类辅助生殖技术中种植前诊断的动物实验研究及临床前期研究,67页,R71
  17. 胰岛素样生长因子IIGF-I对卵泡发育调控作用的研究,95页,R71
  18. 细胞因子在子宫内膜异位症免疫学发病机制中作用的研究,88页,R71
  19. 输卵管积水对体外受精-胚胎移植IVF-ET结果的影响及机理探讨,50页,R71
  20. 安徽某农村地区妇女智力缺陷现况及其生殖健康危害研究,65页,R71
中图分类: > R73 > 医药、卫生 > 肿瘤学

© 2012 book.hzu.edu.cn